3D Electron Microscopy Of Molecular Assemblies
Zhang Lab University of Pittsburgh School of Medicine Department of Structural Biology
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Postdoctoral or research associate positions are available in our laboratory in the Dept. of Structural Biology at Univ. of Pittsburgh Medical Center. Our research is mainly focused on structural and functional studies of macromolecular assemblies using cryo-EM (including electron tomography, single particle or helical analysis and 2D electron crystallography), combined with a variety of complementary biochemical and computational methods. Areas of interest include study of 1) HIV-1 and host cell interactions; 2) Transmembrane receptor signaling in bacterial chemotaxis; 3) correlative fluorescence and cryo-electron microscopy. The laboratory is fully equipped with state-of-the-art electron microscopy instrumentation for cryo-EM analysis, including a FEI Polara 300kv helium stage with a high-resolution 4kx4k CCD camera, a TF20 FEG with 4kx4k CCD camera, a T12spirit, and an FEI vitrobot for specimen preparation. The laboratory is also fully set up for modern molecular biology and protein biochemistry and has access to the protein expression and purification facilities, state-of-the-art NMR spectrometers and X-ray crystallography within the department. Qualifications include a Ph.D. and an interest in the structural biology of complex molecular assemblies. Experience in HRTEM, image processing and 3D reconstruction, and cell biology/protein biochemistry is desirable.

The graduate program in molecular biophysics at the University of Pittsburgh is an interdisciplinary program at the interfaces of Biology, Chemistry, Physics and other traditional disciplines. Molecular Biophysics aims to unravel and explain biological phenomena and processes in atomic and molecular detail. Position for MBSB graduate student is available.

For more information visit MSBS Graduate Program web page.

Motivated candidate with strong interest in structural biology of molecular complexes and solid background in biophysics/physics/material science are all encouraged to apply.  Potential candidates should send a PDF including a cover letter, curriculum vitae with list of publications, and names of three referees to:

Peijun Zhang
Associate Professor
Dept. of Structural Biology
Univ. of Pittsburgh School of Medicine
3501 5th Ave, Pittsburgh, PA 15260
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